Sedation and analgesia. Part 3-specific drugs

Welcome to your Sedation and analgesia. Part 3-specific drugs

Propofol is dissolved in a white lipid (fat) solution that contains calories. The same fat used in TPN

Propofol is also an anticonvulsant

Giving a 2 ml bolus of Propofol when increasing the rate of infusion or for agitated patients may be helpful and has no risks

Although Lorazepam has a long half life it has no active metabolites that could accumulate in the blood

Midazolam infusions may be run together with Propofol and Alfentanil

Midazolam has active metabolites

Alfentanil is ten times more potent than Morpine

The respiratory depression caused by Alfentanil can be an advantage

Clonidine was first introduced as a hypotensive agent to treat hypertension due to it's central action to reduce blood pressure

Clonidine may help patients withdrawing from drugs or alcohol

Ketamine should never be given to patients with head injuries

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